Age your Best
We can't control everything, but there's a lot we can do to boost our body's natural aging processes.
McKinsey Health Institute recently asked a crucial question: "Why are we living longer but not healthier?"ยน
This question highlights the gap between modern advancements to extend our lifespanโby an average of 19 yearsโwithout a corresponding improvement to the quality of those additional years:
We canโt control everything about how we age, but we can do a lot to improve our health with the time we have. Thatโs the premise of Healthy Aging, which is the foundational focus of Truly Essential products.
Balance and Healthy Aging
A key to unlocking the complexities of aging is by restoring our internal balance. That's because our bodies naturally work to create homeostasis, a critical balance that influences cellular health, stress and inflammation responses, immunity, and more. As we age this balancing act gets harder, leading to inefficiencies and imbalances that can accelerate the aging process.
We believe itโs essential to restore our body's natural mechanisms and help create a strong foundation for healthy aging. Our Core Essential System specifically targets some of the biggest factors of healthy aging: cellular hydration, inflammation, and immunity. We are launching with a line of intracellular hydration products.
Plenty of products claim to address aging effectively, but many only target the symptoms without tackling the underlying causes. The products in the Core Essential system work together to restore balance at the cellular level and support healthy aging. Intracellular hydration is fundamental to healthy aging, serving as the cornerstone for maintaining cellular health and function as we grow older. Proper hydration at the cellular level ensures that cells can effectively absorb nutrients and expel waste, crucial processes that support overall vitality and longevity. Additionally, well-hydrated cells are better equipped to combat inflammation and support a robust immune system, two critical factors in aging healthily.
The Full Spectrum of Aging
There are 14 key factors that contribute to aging, highlighting how complex the process truly is. No product can effectively target them all, but strengthening your bodyโs response to aging can have a hugely positive impact. Focusing on cellular hydration, inflammation, and immunity equips you with effective strategies to maintain balance and enhance your body's natural capabilities.
14 key aging factors backed by science:
Research indicates the critical role of hydration in maintaining cellular health, with studies in "Aging Research Reviews" discussing how cellular hydration impacts overall aging.โท
A study published in "Nature Reviews Immunology" delves into the intricate interplay between genomic instability and immune responses, shedding light on how immune mechanisms combat DNA damage during aging.โธ
"Nature Reviews Genetics" offers insights into how epigenetic changes, including DNA methylation and histone modification, affect the aging process.โน
The link between telomere length and cellular aging is detailed in "Cell", describing how shortened telomeres lead to cell senescence and aging.ยนโฐ
Studies in "Science" illustrate how mitochondrial efficiency declines with age, affecting energy production and increasing oxidative stress.ยนยน
"Cell Stem Cell" highlights research on how the decline in stem cell function contributes to aging and impaired tissue regeneration.ยนยฒ
The "Annual Review of Physiology" discusses the accumulation of senescent cells with age and its impact on aging and disease.ยนยณ
Coined in the "Journal of Gerontology", this term describes the chronic, low-grade inflammation that characterizes aging, contributing to many age-related diseases.ยนโด
"Nature Reviews Molecular Cell Biology" reviews how the balance of protein synthesis, folding, and degradation is disrupted in aging, leading to disease.ยนโต
The "Journal of Molecular Biology" discusses how aging affects the pathways that sense and respond to nutrients, impacting metabolism and lifespan.ยนโถ
Research in "Science Translational Medicine" explores changes in hormonal and neuronal signals with age, affecting systemic aging.ยนโท
"Autophagy" details how the decline in autophagy, the process of clearing damaged cells, contributes to aging and age-related diseases.ยนโธ
"Nature Medicine" reviews studies on how changes in the gut microbiome with age affect health and disease susceptibility.ยนโน
"Aging Cell" discusses the impact of structural protein degradation on tissue function and the aging process, highlighting the importance of maintaining protein integrity.ยฒโฐ
Finding Balance in Aging
Homeostasis and Aging
Research in "Cell Metabolism" outlines how aging disrupts homeostasis in various biological systems, emphasizing the importance of cellular health in aging.ยฒ
Inflammation and Aging
A pivotal study in the "Journal of Gerontology" discusses the role of chronic inflammation in aging, coining the term "inflammaging" as a significant contributor to age-related diseases.ยณ
Immunity and Aging
A study published in "Nature Reviews Immunology" looks at the connection between genomic instability and immune responses, and how immune mechanisms combat DNA damage during aging.โธ
Identifying the Truly Essential Factors
Environmental and Lifestyle Factors on Aging
Aging and Genetics
Healthy Aging Resources
The National Institute on Aging provides resources and guides on healthy aging, supporting the journey towards a vibrant, healthier life.ยฒโฐ
- World Health Organization. "Healthy Aging and Functional Ability."
- Lรณpex-Otรญn, C., et al. "The Hallmarks of Aging." Cell Metabolism.
- Franceschi, C., et al. "Inflammaging: A new immune-metabolic viewpoint for age-related diseases." Journal of Gerontology.
- Fontana, L. et al. "Promoting Health and Longevity through Diet: From Model Organisms to Humans." Science.
- Ezzati, M., et al. "Lifestyle and Life Expectancy." Lancet Public Health.
- Booth, L.A., et al. "The Genetics of Aging." Nature.
- Ritz, P., "Effects of Changes in Water Intake on Aging-Related Diseases," Aging Research Reviews.
- Soria-Valles, C., Lรณpez-Soto, A., Osorio, F.G., Lรณpez-Otรญn, C., "Immune and inflammatory responses to DNA damage in cancer and aging," Mechanisms of Ageing and Development.
- Bird, A., "Perceptions of Epigenetics," Nature Reviews Genetics.
- Blackburn, E.H., "Telomeres and Telomerase: Their Mechanisms of Action and the Effects of Altering Their Functions," FEBS Letters.
- Wallace, D.C., "Mitochondria and Cancer: Warburg Addressed," Cold Spring Harbor Symposia on Quantitative Biology.
- Sharpless, N.E., DePinho, R.A., "How Stem Cells Age and Why This Makes Us Grow Old," Nature.
- Tchkonia, T., Kirkland, J.L., "Cellular Senescence and the Senescent Secretory Phenotype: Therapeutic Opportunities," The Journal of Clinical Investigation.
- Franceschi, C., Campisi, J., "Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases," The Journals of Gerontology: Series A.
- Morimoto, R.I., Cuervo, A.M., "Protein Homeostasis and Aging: The Importance of Exquisite Quality Control," Ageing Research Reviews.
- Efeyan, A., Comb, W.C., Sabatini, D.M., "Nutrient-sensing Mechanisms and Pathways," Nature.
- Blau, H.M., Cosgrove, B.D., Ho, A.T.V., "The Central Role of Muscle Stem Cells in Regenerative Failure with Aging," Nature Medicine.
- Levine, B., Kroemer, G., "Autophagy in the Pathogenesis of Disease," Cell.
- O'Toole, P.W., Jeffery, I.B., "Gut Microbiota and Aging," Science.
- Kagan, V.E., et al., "Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors.โ National Institute on Aging. "Health Information."